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Products Details
Product Description
– AuM1Phe, an N-Heterocyclic carbene (NHC) metal complexe, blocks the human topoisomerase I activity and actin polymerization reaction. AuM1Phe affects the growth of MDA-MB-231 breast cancer cells, with an IC50 value of 1.2 μM[1].
Web ID
– HY-156403
Shipping
– Room temperature
Molecular Formula
– C26H30AuCl2N3O5
References
– [1]Domenico Iacopetta, et al. NHC-Ag(I) and NHC-Au(I) Complexes with N-Boc-Protected α-Amino Acidate Counterions Powerfully Affect the Growth of MDA-MB-231 Cells. ACS Med. Chem. Lett. 2023.
Molecular Weight
– 732.40
SMILES
– OC(C1=CC=CC=C1)CN(C2[Au]OC([C@H](CC3=CC=CC=C3)NC(OC(C)(C)C)=O)=O)C(Cl)=C(N2C)Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Topoisomerase
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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