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Products Details
Product Description
– ATX inhibitor 14 (compound 4), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 0.41 nM. ATX inhibitor 14 has the potential for fibrosis relevant diseases research[1].
Web ID
– HY-143419
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H26Cl2N4O3S
References
– [1]Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951.
CAS Number
– 2484811-39-2
Molecular Weight
– 545.48
SMILES
– O=C(NC1=CN(CC)C2=C1C=C(C3=NC(CN4CCOCC4)=CS3)C=C2)OCC5=CC(Cl)=CC(Cl)=C5
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– Autotaxin
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
