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Product Description
– ATX inhibitor 13 (10c) is an orally active and potent ATX inhibitor, with an IC50 of 3.4 nM. ATX inhibitor 13 inhibits proliferation and migration, and induces apoptosis and G2 phase arrest in RAW264.7 cells. ATX inhibitor 13 suppresses tumor cell colony formation[1].
Web ID
– HY-144766
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H35Cl2N5O3
References
– [1]Lei H, et al. Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors. Eur J Med Chem. 2022;236:114307.
CAS Number
– 2485779-34-6
Molecular Weight
– 596.55
SMILES
– O=C(OCC1=CC(Cl)=CC(Cl)=C1)NC2=C(CC)N=C3C(C)=CC(C4=CC=C(CN5CCN(CCO)CC5)C=C4)=CN32
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
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