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Products Details
Product Description
– ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research[1].
Web ID
– HY-143237
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C32H35N5O6
References
– [1]Lei H, et al. Novel imidazo[1,2-a]pyridine derivatives as potent ATX allosteric inhibitors: Design, synthesis and promising in vivo anti-fibrotic efficacy in mice lung model. Bioorg Chem. 2022 Mar;120:105590.
CAS Number
– 2485779-27-7
Molecular Weight
– 585.65
SMILES
– CCC1=C(N2C=C(C=C(C2=N1)C)C3=CC=C(C=C3)C(N4CCN(CC4)CCO)=O)NC(OCC5=CC6=C(OCO6)C=C5)=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– Autotaxin
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
