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Atropine (sulfate)
$60
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Products Details
Product Description
– Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia[1][2][3][4].
Web ID
– HY-B1205A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C17H23NO3.1/2H2SO4
Citations
– Arch Oral Biol. 2022: 105586.|Can J Physiol Pharmacol. 2020 Oct;98(10):725-732.|Cell Metab. 2022 Nov 11;S1550-4131(22)00490-9.|Cell Rep. 2022 Mar 8;38(10):110468.|Food Chem. 30 November 2022, 133593.|Front Pharmacol. 2020 Jul 31;11:1038.|J Biosci. 2021;46:90.|J Ethnopharmacol. 2023 Sep 19;117192.|Research Square Preprint. 2022 Mar.|Research Square Print. 2023 Feb 7.|Research Square Print. December 16th, 2022.|Cell Discov. 2023 Feb 7;9(1):16.|Neuron. 2022 Sep 14;S0896-6273(22)00796-6.
References
– [1]McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8.|[2]Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57.|[3]Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791.|[4]Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8.
CAS Number
– 55-48-1
Molecular Weight
– 338.41
Compound Purity
– 99.74
SMILES
– O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C(CO)C3=CC=CC=C3.[0.5H2SO4]
Clinical Information
– Launched
Research Area
– Neurological Disease; Cardiovascular Disease
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)|H2O : 100 mg/mL (ultrasonic)
Target
– mAChR
Isoform
– mAChR4
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
