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Atrasentan
$120 – $780
Products Details
Product Description
– Atrasentan (ABT-627) is an endothelin receptor antagonist with IC50 of 0.0551 nM for ETA[1].
Web ID
– HY-15403
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C29H38N2O6S
Citations
– Commun Biol. 2022 Jul 28;5(1):750.|Eur J Pharmacol. 2019 Mar 12;852:142-150.|Department Veterinary Clinical Medicine. University of Illinois. 2015.|J Vet Intern Med. 2015 Nov;29(6):1584-94.|Mol Immunol. 2019 Oct;114:10-18.Â
References
– [1]Weiss J, et al. Interaction potential of the endothelin-A receptor antagonist atrasentan with drug transporters and drug-metabolising enzymes assessed in vitro. Cancer Chemother Pharmacol. 2011 Oct;68(4):1093-8.|[2]Yuyama H, et al. Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist. Eur J Pharmacol. 2004 Sep 13;498(1-3):171-7.|[3]Banerjee S, et al. In vitro and in vivo molecular evidence for better therapeutic efficacy of ABT-627 and taxotere combination in prostate cancer. Cancer Res. 2007 Apr 15;67(8):3818-26.
CAS Number
– 173937-91-2
Molecular Weight
– 542.69
Compound Purity
– 99.58
SMILES
– O=C([C@H]1[C@H](C2=CC=C(OC)C=C2)N(CC(N(CCCC)CCCC)=O)C[C@@H]1C3=CC=C(OCO4)C4=C3)O.[S].[R].[R]
Clinical Information
– Launched
Research Area
– Cancer; Endocrinology; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Endothelin Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
