Products Details

Product Description

– ATR-IN-6 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-6 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021233376A1, compound A22)[1].

Web ID

– HY-142672

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C28H28FN7O2

References

– [1]Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent WO2021233376A1.

CAS Number

– 2746446-99-9

Molecular Weight

– 513.57

SMILES

– OCC1=CC(C2=NC(N3[C@@H](COCC3)C)=CC(C4=C(N(C5=CN=CC(F)=C5)N=C4C)C)=N2)=C6C(NC=C6)=C1

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– ATM/ATR

Pathway

– Cell Cycle/DNA Damage;PI3K/Akt/mTOR

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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