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Products Details
Product Description
– ATR-IN-6 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-6 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021233376A1, compound A22)[1].
Web ID
– HY-142672
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C28H28FN7O2
References
– [1]Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent WO2021233376A1.
CAS Number
– 2746446-99-9
Molecular Weight
– 513.57
SMILES
– OCC1=CC(C2=NC(N3[C@@H](COCC3)C)=CC(C4=C(N(C5=CN=CC(F)=C5)N=C4C)C)=N2)=C6C(NC=C6)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
