![](https://immunomart.com/wp-content/uploads/2024/03/HY-145312.gif)
Download Files:
ATR-IN-4
SKU
HY-145312-10 mg
Category Reference compound
Tags ATM/ATR, Cancer, Cell Cycle/DNA Damage;PI3K/Akt/mTOR
$750 – $6,500
Products Details
Product Description
– ATR-IN-4 is a potent ATR (Ataxia telangiectasia mutated gene Rad 3-associated kinase) inhibitor. ATR-IN-4 inhibits growth of human prostate cancer cells DU145 and human lung cancer cells NCI-H460 with IC50s of 130.9 nM and 41 .33 nM, respectively. (Patent CN112142744A, compound 13)[1].
Web ID
– HY-145312
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H20N8O
References
– [1]Substituted fused heteroaromatic bicyclic compounds as kinase inhibitors and uses thereof. CN112142744A.
CAS Number
– 2574545-45-0
Molecular Weight
– 364.40
Compound Purity
– 99.17
SMILES
– CN1C(C2=CC(N3[C@@H](COCC3)C)=NN4C2=CN=C4C5=NNC=C5)=CC=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 25 mg/mL (ultrasonic)
Target
– ATM/ATR
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.