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Products Details
Product Description
– ATR-IN-23 (Compound 34) is a potent and selective ATR inhibitor with an IC50 of 1.5 nM. ATR-IN-23 has potent antiproliferative effects on LoVo cells and synthetic lethality on HT-29 cells, and can be used in the study of DNA damage response (DDR)-deficient cancers[1].
Web ID
– HY-149952
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H22N6O3S2
References
– [1]Duan Y, et al. Discovery of Thieno[3,2-d]pyrimidine derivatives as potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) kinase. Eur J Med Chem. 2023 Jul 5;255:115370.
CAS Number
– 2923800-62-6
Molecular Weight
– 458.56
SMILES
– CNC1=NC2=C(N1C3=NC4=C(C(N5CCOC[C@H]5C)=N3)SC=C4S(C)(=O)=O)C=CC=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
