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Products Details
Product Description
– ATR-IN-18 (compound 2) is an orally active and potent ATR kinase inhibitor, with an IC50 of 0.69 nM. ATR-IN-18 shows antiproliferative activity in LoVo cells, with an IC50 of 37.34 nM. ATR-IN-18 has anti-tumor activity[1].
Web ID
– HY-147570
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H22F3N7O5S
References
– [1]Xiaohui Liu, et al. Triheterocyclic derivative, and pharmaceutical composition and application thereof. WO2022078480A1.
CAS Number
– 2766407-55-8
Molecular Weight
– 517.48
SMILES
– OC(C(F)(F)F)=O.CS(=O)(N1C2=C(CC1)C(N3[C@@H](COCC3)C)=NC4=C2C=NN4C5=NNC=C5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR
Isoform
– ATR
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
