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Products Details
Product Description
– ATR-IN-18 (compound 2) is an orally active and potent ATR kinase inhibitor, with an IC50 of 0.69 nM. ATR-IN-18 shows antiproliferative activity in LoVo cells, with an IC50 of 37.34 nM. ATR-IN-18 has anti-tumor activity[1].
Web ID
– HY-147570
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H22F3N7O5S
References
– [1]Xiaohui Liu, et al. Triheterocyclic derivative, and pharmaceutical composition and application thereof. WO2022078480A1.
CAS Number
– 2766407-55-8
Molecular Weight
– 517.48
SMILES
– OC(C(F)(F)F)=O.CS(=O)(N1C2=C(CC1)C(N3[C@@H](COCC3)C)=NC4=C2C=NN4C5=NNC=C5)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR
Isoform
– ATR
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
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