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Products Details
Product Description
– ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].
Web ID
– HY-147567
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H22N8O
References
– [1]Xin Li, et al. Imidazopyrimidine derivative, preparation method therefor and medical use thereof. WO2022002243A1.
CAS Number
– 2756665-52-6
Molecular Weight
– 378.43
SMILES
– CC1=NC(C2=CC=NN2)=C3N=C(C=C(N13)N4[C@H](C)COCC4)C5=CC=NN5C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR;DNA-PK;PI3K
Isoform
– ATM;ATR;PI3K
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
