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Products Details
Product Description
– ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC50 of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC50 values of 47, 663 and 5131 nM, respectively[1].
Web ID
– HY-147567
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C19H22N8O
References
– [1]Xin Li, et al. Imidazopyrimidine derivative, preparation method therefor and medical use thereof. WO2022002243A1.
CAS Number
– 2756665-52-6
Molecular Weight
– 378.43
SMILES
– CC1=NC(C2=CC=NN2)=C3N=C(C=C(N13)N4[C@H](C)COCC4)C5=CC=NN5C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR;DNA-PK;PI3K
Isoform
– ATM;ATR;PI3K
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
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