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Products Details
Product Description
– ATR-IN-11 (Compound Hit01) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. ATR kinase is a key regulating protein within the DNA damage response (DDR), responsible for sensing replication stress (RS). ATR-IN-11 is a promising lead compound for subsequent agent discovery targeting ATR kinase. ATR-IN-11 has the potential for the research of cancer disease[1].
Web ID
– HY-144435
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C25H30N6O2
References
– [1]Chen P, et al. Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors. Bioorg Med Chem Lett. 2022;63:128651.
Molecular Weight
– 446.54
SMILES
– O=C(N1CC2=NC(C3=CNC4=C3C=CC=C4)=NC(N5[C@@H](COCC5)C)=C2C1)C6CCNCC6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
