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Products Details
Product Description
– ATP-18O4 (disodium salt) is the 18O labeled ATP disodium salt[1]. ATP disodium salt (Adenosine 5′-triphosphate disodium salt) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt is an important endogenous signaling molecule in immunity and inflammation[2][3].
Web ID
– HY-B0345AS
Shipping
– Room temperature
Molecular Formula
– C10H16N5NaO9 18O4P3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Bonora M, et al. ATP synthesis and storage. Purinergic Signal. 2012 Sep;8(3):343-57.|[3]M J L Bours, et al. Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov112(2):358-404.|[4]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov107:104514.|[5]Yang Xiang, et al. Adenosine-5′-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013 8(5): e63759.
CAS Number
– 2483830-61-9
Molecular Weight
– 538.17
SMILES
– O[C@H]1[C@](O[C@@H]([C@H]1O)COP(OP([18O]P([18OH])([18OH])=[18O])(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2.[Na]
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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