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Product Description
– ATP-13C10,15N5 is the 13C and 15N labeled ATP[1]. ATP (Adenosine 5′-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation[2][3].
Web ID
– HY-B2176S
Shipping
– Room temperature
Molecular Formula
– 13C10H16 15N5O13P3
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Swennen EL, et al. Immunoregulatory effects of adenosine 5′-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.|[3]M J L Bours, et al. Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov112(2):358-404.|[4]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov107:104514.|[5]Yang Xiang, et al. Adenosine-5′-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013 8(5): e63759.
CAS Number
– 752972-20-6
Molecular Weight
– 522.07
SMILES
– [15NH2][13C]1=[13C]2[13C]([15N]([13C@@H]3O[13C@H]([13CH2]OP(OP(O)(OP(O)(O)=O)=O)(O)=O)[13C@@H](O)[13C@H]3O)[13CH]=[15N]2)=[15N][13CH]=[15N]1
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Endogenous Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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