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Atorvastatin-d5 (sodium)
SKU
HY-B0589S1-1 mg
Category Isotope-Labeled Compounds
Tags Autophagy;HMG-CoA Reductase (HMGCR), Autophagy;Metabolic Enzyme/Protease, Metabolic Disease; Inflammation/Immunology
Products Details
Product Description
– Atorvastatin-d5 (sodium) is the deuterium labeled Atorvastatin sodium. Atorvastatin sodium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin sodium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3][4].
Web ID
– HY-B0589S1
Shipping
– Room temperature
Molecular Formula
– C33H29D5FN2NaO5
References
– [1]Santodomingo-Garzón T, et al. Atorvastatin inhibits inflammatory hypernociception. Br J Pharmacol. 2006 Sep;149(1):14-22.|[2]Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
CAS Number
– 222412-87-5
Molecular Weight
– 585.65
SMILES
– O=C(C1=C(C(C)C)N(CC[C@@H](O)C[C@@H](O)CC(O[Na])=O)C(C2=CC=C(C=C2)F)=C1C3=C([2H])C([2H])=C([2H])C([2H])=C3[2H])NC4=CC=CC=C4
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Autophagy;HMG-CoA Reductase (HMGCR)
Pathway
– Autophagy;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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