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Products Details
Product Description
– ATM Inhibitor-2 (compound 7) is a potent and selective ATM inhibitor, with an IC50 of <1 nM[1].
Web ID
– HY-144685
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H31N7O3
References
– [1]Dimitrov T, et al. Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Eur J Med Chem. 2022 May 5;235:114234.
CAS Number
– 2769140-29-4
Molecular Weight
– 489.57
SMILES
– CN(CCNC(NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(N4C)=O)C5CCOCC5)C3=C2)=O)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR
Isoform
– ATM
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
