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Products Details
Product Description
– Atecegatran metoxil is a oral anticoagulant, which inhibits thrombin factor II and is used in thromboembolic disorders. In vivo, Atecegatran metoxil is converted to AR-H067637, a selective and reversible direct thrombin inhibitor.
Web ID
– HY-10273
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C22H23ClF2N4O5
References
– [1]Lip GY, Rasmussen LH, Olsson SB, et al. Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists. Eur Heart J. 2009;30(23):2897-2907. |[2]Olsson SB, Rasmussen LH, Tveit A, et al. Safety and tolerability of an immediate-release formulation of theoral direct thrombin inhibitor AZD0837 in the prevention of stroke and systemic embolism in patients with atrial fibrillation. Thromb Haemost. 2010;103(3):604-612.
CAS Number
– 433937-93-0
Molecular Weight
– 496.89
SMILES
– O=C([C@H](O)C1=CC(OC(F)F)=CC(Cl)=C1)N(CC2)[C@@H]2C(NCC3=CC=C(C=C3)C(NOC)=N)=O
Clinical Information
– Phase 2
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Thrombin
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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