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Ataluren
$42 – $317
Products Details
Product Description
– Ataluren (PTC124) is an orally available CFTR-G542X nonsense allele inhibitor.
Web ID
– HY-14832
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C15H9FN2O3
References
– [1]Pettit RS, et al. CFTR Modulators for the Treatment of Cystic Fibrosis. P T. 2014 Jul;39(7):500-11.|[2]Welch EM, et al. PTC124 targets genetic disorders caused by nonsense mutations. Nature, 2007, 447(7140), 87-91.|[3]Miller JN, et al. The novel Cln1(R151X) mouse model of infantile neuronal ceroid lipofuscinosis (INCL) for testing nonsense suppression therapy. Hum Mol Genet. 2015 Jan 1;24(1):185-96.
CAS Number
– 775304-57-9
Molecular Weight
– 284.24
Compound Purity
– 99.82
SMILES
– O=C(C1=CC=CC(C2=NOC(C3=CC=CC=C3F)=N2)=C1)O
Clinical Information
– Launched
Research Area
– Metabolic Disease; Cancer
Solubility
– DMSO : ≥ 52 mg/mL
Target
– Autophagy;CFTR
Pathway
– Autophagy;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
