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ASP2453
$620 – $3,050
Products Details
Product Description
– ASP2453 is a potent, selective and covalent KRAS G12C inhibitor. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf with an IC50 value of 40 nM.
Web ID
– HY-132966
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C40H48F3N7O4
References
– [1]Nakayama A, et al. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models. Br J Cancer. 2021 Nov 18.
CAS Number
– 2241719-73-1
Molecular Weight
– 747.85
Compound Purity
– 98.04
SMILES
– C=CC(N1CC2(CCN(C3=C4C=C(C5CC5)C(C6=C(C)C=CC7=C6C=NN7)=C(OCC(F)(F)F)C4=NC(OC8CCN(CCCOC)CC8)=N3)CC2)C1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Ras
Isoform
– K-Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
