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Products Details
Product Description
– ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC50 values of 7.12 nM, 517 nM for hS1P1 and hS1P3, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile[1].
Web ID
– HY-125881
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C26H26ClF6NO5
References
– [1]Okimoto A, et al. ASP1126, a Novel Sphingosine-1-Phosphate-Selective Agonist With a Favorable Safety Profile, Prolongs Allograft Survival in Rats and Nonhuman Primates in Combination With Tacrolimus With a Broad Safety Margin for Bradycardia. Transplant Proc. 2019 Jul – Aug;51(6):2081-2098.
CAS Number
– 1228580-11-7
Molecular Weight
– 581.93
SMILES
– O=C(C1CCN(CC2=CC3=CC=C(OCC4=CC=C(OCC(F)(F)F)C(C(F)(F)F)=C4)C=C3OC2)CC1)O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– LPL Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
