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ASK1-IN-1
$130 – $2,695
Products Details
Product Description
– ASK1-IN-1 is a CNS-penetrant ASK1 (apoptosis signal-regulating kinase 1) inhibitor, with good potency (cell IC50=138 nM; Biochemical IC50=21 nM)[1].
Web ID
– HY-133554
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H19N9O2
References
– [1]Xin Z, et al. Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors. ACS Med Chem Lett. 2020;11(4):485-490. Published 2020 Feb 12.
CAS Number
– 2411382-24-4
Molecular Weight
– 405.41
Compound Purity
– 99.80
SMILES
– COC1=NN(C2=NC=CN=C2)C=C1C(NC3=NC(C4=NN=CN4C(C)C)=CC=C3)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMF : 4 mg/mL (ultrasonic)|DMSO : < 1 mg/mL|Ethanol : < 1 mg/mL (ultrasonic)
Target
– p38 MAPK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
