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Ascochlorin
$677
Only 1000 item(s) left in stock.
Products Details
Product Description
– Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis. Anti-inflammatory activity[1][2][3].
Web ID
– HY-101021
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H29ClO4
References
– [1]Min-Wen JC, et al. Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy. Adv Protein Chem Struct Biol. 2017;108:199-225.|[2]Lee SH, et al. Anti-Inflammatory Effect of Ascochlorin in LPS-Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down-Regulation of iNOS, COX-2 and Proinflammatory Cytokines Through NF-κB, ERK1/2, and p38 Signaling Pathway. J Cell Biochem. 2016 Apr;117(4):978-87.|[3]Dai X, et al. Ascochlorin, an isoprenoid antibiotic inhibits growth and invasion of hepatocellular carcinoma by targeting STAT3 signaling cascade through the induction of PIAS3. Mol Oncol. 2015 Apr;9(4):818-33.
CAS Number
– 26166-39-2
Molecular Weight
– 404.93
SMILES
– O=CC1=C(O)C(C/C=C(C)/C=C/[C@]2(C)[C@@H](C)C(CC[C@H]2C)=O)=C(O)C(Cl)=C1C
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Apoptosis;STAT
Isoform
– STAT3
Pathway
– Anti-infection;Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
