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AS601245
SKU
HY-11010-10 mg
Category Reference compound
Tags Cancer; Inflammation/Immunology; Neurological Disease, JNK, MAPK/ERK Pathway
$120 – $1,350
Products Details
Product Description
– AS601245 is an orally active, selective, ATP competitive JNK (c-Jun NH2-terminal protein kinase) inhibitor with IC50s of 150, 220, and 70 nM for three JNK human isoforms (hJNK1, hJNK2, and hJNK3), respectively. AS601245 exhibits 10- to 20-fold selectivity over c-src, CDK2, and c-Raf and more than 50- to 100-fold selectivity over a range of Ser/Thr- and Tyr-protein kinases. Neuroprotective properties[1][2].
Web ID
– HY-11010
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H16N6S
References
– [1]Carboni S, et al. AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties. J Pharmacol Exp Ther. 2004;310(1):25-32.
CAS Number
– 345987-15-7
Molecular Weight
– 372.45
Compound Purity
– 98.83
SMILES
– N#CC(C1=CC=NC(NCCC2=CC=CN=C2)=N1)C3=NC4=CC=CC=C4S3
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 10 mg/mL (ultrasonic)
Target
– JNK
Isoform
– JNK1;JNK2;JNK3
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
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