Download Files:
AS2444697
$110 – $950
Products Details
Product Description
– AS2444697 is an orally active IRAK-4 inhibitor with an IC50 of 21 nM[1]. AS2444697 potently inhibits human and rat IRAK-4 activity. AS2444697 exhibits renoprotective effects through anti-inflammatory action[2].
Web ID
– HY-18992
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H21ClN6O4
References
– [1]JohnHynesJr, et al. Chapter Nine – Advances in the Discovery of Small-Molecule IRAK4 Inhibitors. Annu Rep Med Chem. 2014 (49):117-133.|[2]Mitsuhiro Kondo, et al. Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats. Naunyn Schmiedebergs Arch Pharmacol. 2014 Oct;387(10):909-19.
CAS Number
– 1287665-60-4
Molecular Weight
– 432.86
Compound Purity
– 99.12
SMILES
– O=C(NC1=CN(C2CCOCC2)N=C1C(N)=O)C3=COC(C4=CC=NC(C)=C4)=N3.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : ≥ 12.5 mg/mL
Target
– IRAK
Isoform
– IRAK4
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
