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Products Details
Product Description
– AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 µM, Kd= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo[1].
Web ID
– HY-141429C
Shipping
– Room temperature
Molecular Formula
– C27H31ClF3N5O3S2
References
– [1]Rogawski DS, et al. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 May 14;12(1):2792.
Molecular Weight
– 630.14
SMILES
– O=C(C1CN(C)C1)NCC2=CC3=C(C=C2)C(C4=CC=CC(C(N)=S)=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Histone Methyltransferase
Isoform
– ASH1L/KMT2H
Pathway
– Apoptosis;Epigenetics
Product type
– Reference compound
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