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Products Details
Product Description
– ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research[1].
Web ID
– HY-115498
Shipping
– Room temperature
Molecular Formula
– C24H32N4O3
References
– [1]De Vita T, et al. Inhibition of Serine Palmitoyltransferase by a Small Organic Molecule Promotes Neuronal Survival after Astrocyte Amyloid Beta 1-42 Injury. ACS Chem Neurosci. 2019 Mar 20;10(3):1627-1635.
CAS Number
– 1037837-27-6
Molecular Weight
– 424.54
SMILES
– O=C(C1=CC2=C(N(C3CCN(CC(N4CC5C(CCC5)C4)=O)CC3)C(C2)=O)C=C1)NC
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;COX;Interleukin Related;NO Synthase
Isoform
– COX-2;IL-1;iNOS
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
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