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Products Details
Product Description
– Aristolactam BIII is a potent DYRK1A inhibitor and inhibits the kinase activity of DYRK1A in vitro (IC50= 9.67 nM. Aristolactam BIII rescues the proliferative defects of DYRK1A transgenic (TG) mouse-derived fibroblasts and neurological and phenotypic defects of DS-like Drosophila models[1].
Web ID
– HY-122989
Shipping
– Room temperature
Molecular Formula
– C18H15NO4
References
– [1]Miri Choi, et al. Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes. Phytomedicine. 2021 Nov:92:153695.
CAS Number
– 53948-10-0
Molecular Weight
– 309.32
SMILES
– O=C1NC2=C3C1=CC(OC)=C(OC)C3=C4C(C=CC(OC)=C4)=C2
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– DYRK
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
