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Aripiprazole (monohydrate)

SKU HY-14546A-Get quote Category Reference compound Tags 5-HT Receptor;Dopamine Receptor, GPCR/G Protein;Neuronal Signaling, Infection; Inflammation/Immunology; Neurological Disease

Products Details

Product Description

– Aripiprazole (OPC-14597) monohydrate, an atypical antipsychotic, is a potent and high-affinity dopamine D2 receptor partial agonist. Aripiprazole monohydrate is an inverse agonist at 5-HT2B and 5-HT2A receptors and displays partial agonist actions at 5-HT1A, 5-HT2C, D3, and D4 receptors. Aripiprazole monohydrate can be used for the research of schizophrenia and COVID19[1][2][3][4].

Web ID

– HY-14546A

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C23H29Cl2N3O3

References

– [1]Burris KD, et al. Aripiprazole, a novel antipsychotic, is a high-affinity partial agonist at human dopamine D2 receptors. J Pharmacol Exp Ther. 2002 Jul;302(1):381-9.|[2]Davies MA, et al. Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev. 2004 Winter;10(4):317-36.|[3]Crespo-Facorro B, et al. Aripiprazole as a Candidate Treatment of COVID-19 Identified Through Genomic Analysis. Front Pharmacol. 2021 Mar 2;12:646701.|[4]Russo E, et al. Ameliorating effects of aripiprazole on cognitive functions and depressive-like behavior in a genetic rat model of absence epilepsy and mild-depression comorbidity. Neuropharmacology. 2013 Jan;64:371-9.

CAS Number

– 851220-85-4

Molecular Weight

– 466.40

SMILES

– O=C1NC2=C(C=CC(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CC1.O

Clinical Information

– Launched

Research Area

– Infection; Inflammation/Immunology; Neurological Disease

Solubility

– 10 mM in DMSO

Target

– 5-HT Receptor;Dopamine Receptor

Isoform

– 5-HT1 Receptor;5-HT2 Receptor;D2 Receptor;D3 Receptor;D4 Receptor

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.