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Products Details
Product Description
– Aplithianines A is a potent inhibitor against J-PKAcα with an IC50 of 1 μM , and inhibits wild-type PKA with an IC50 of 84 nM. Aplithianines A inhibits J-PKAcα catalytic activity by competitively binding to the ATP pocket[1].
Web ID
– HY-N12399
Shipping
– Room temperature
Molecular Formula
– C13H13N7S
References
– [1]Du L, et al. Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J Nat Prod. 2023;86(10):2283-2293.
IF: 5.1 Q1 B2
Molecular Weight
– 299.35
SMILES
– CN1C=NC=C1C(SCC2)=CN2C3=NC=NC4=C3N=CN4
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– PKA
Pathway
– Stem Cell/Wnt
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
