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Aplaviroc
SKU
HY-17450-Get quote
Category Reference compound
Tags Anti-infection;GPCR/G Protein;Immunology/Inflammation, CCR;HIV, Infection; Endocrinology
Products Details
Product Description
– Aplaviroc (AK 602), a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW.
Web ID
– HY-17450
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C33H43N3O6
References
– [1]Maeda K, et al. Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro. J Virol. 2004 Aug;78(16):8654-62.|[2]Hirotomo Nakata, et al. Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model. Virol. 2005 Feb;79(4):2087-96.
CAS Number
– 461443-59-4
Molecular Weight
– 577.71
SMILES
– O=C(O)C1=CC=C(OC2=CC=C(CN(CC3)CCC3(N(CCCC)C([C@@H]([C@@H](C4CCCCC4)O)N5)=O)C5=O)C=C2)C=C1
Clinical Information
– Phase 3
Research Area
– Infection; Endocrinology
Solubility
– 10 mM in DMSO
Target
– CCR;HIV
Isoform
– CCR5;HIV-1
Pathway
– Anti-infection;GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
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