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Product Description
– Apatorsen (sodium) is an antisense oligonucleotide designed to bind to Hsp27 mRNA, resulting in the inhibition of the production of Hsp27 protein.
Web ID
– HY-145722
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C224H285N79Na19O116P19S19
References
– [1]Yu EY, Ellard SL, Hotte SJ, et al. A randomized phase 2 study of a HSP27 targeting antisense, apatorsen with prednisone versus prednisone alone, in patients with metastatic castration resistant prostate cancer. Invest New Drugs. 2018;36(2):278-287. |[2]Spigel DR, Shipley DL, Waterhouse DM, et al. A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial. Oncologist. 2019;24(12):e1409-e1416.
CAS Number
– 915443-09-3
Molecular Weight
– 7557.00
SMILES
– [Apatorsen (sodium)]
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in H2O
Target
– HSP
Pathway
– Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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