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AP39
$100 – $1,000
Products Details
Product Description
– AP39 is a triphenylphosphonium derivatised anethole dithiolethione and mitochondria-targeting hydrogen sulfide (H2S) donor. AP39 increases intracellular H2S levels. AP39 exerts cytoprotective effects and maintains mitochondrial DNA integrity under oxidative stress conditions. AP39 protects against myocardial reperfusion injury in mice model and has the potential for Alzheimer’s disease research[1][2][3].
Web ID
– HY-126124
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C37H38BrO2PS3
References
– [1]Feng-Li Zhao, et al. AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons. Oxid Med Cell Longev. 2016;2016:8360738.|[2]Bartosz Szczesny, et al. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide. 2014 Sep 15;41:120-30.|[3]Qutuba G Karwi, et al. AP39, a mitochondria-targeting hydrogen sulfide (H 2 S) donor, protects against myocardial reperfusion injury independently of salvage kinase signaling. Br J Pharmacol. 2017 Feb;174(4):287-301.
CAS Number
– 1429061-80-2
Molecular Weight
– 721.77
Compound Purity
– 95.0
SMILES
– S=C1SSC(C2=CC=C(OC(CCCCCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)C=C2)=C1.[Br-]
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Cardiovascular Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Others
Pathway
– Others
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
