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Product Description
– Antitumor photosensitizer-4 (compound 10b) is a potent tyrosine kinase inhibitor (TKI) targeting ABCG2. Antitumor photosensitizer-4 is a photosensitizer (PS) consisting of a conjugate of dasatinib (HY-10181) and imatinib (HY-15463). Antitumor photosensitizer-4 induces apoptosis and ROS production and exhibits strong phototoxicity to HepG2 and B16-F10 cells[1].
Web ID
– HY-156092
Shipping
– Room temperature
Molecular Formula
– C65H77ClN12O11S
References
– [1]Huang F, et al. Novel chlorin e6-based conjugates of tyrosine kinase inhibitors: Synthesis and photobiological evaluation as potent photosensitizers for photodynamic therapy. Eur J Med Chem. 2023 Sep 5;261:115787.. .
Molecular Weight
– 1269.90
SMILES
– CC1=C(/C=C2[C@@H](C)[C@H](CCC(O)=O)C3=N/2)NC(/C=C4C(C)=C(CC)C(/C=C(N/5)/C(C)=C(C(O)=O)C5=C3/CC(NCCOCCOCCOCCC(OCCN6CCN(C7=CC(NC8=NC=C(C(NC9=C(C)C=CC=C9Cl)=O)S8)=NC(C)=N7)CC6)=O)=O)=N/4)=C1C=C
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;BCRP
Pathway
– Apoptosis;Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
