Download Files:
Products Details
Product Description
– Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells[1].
Web ID
– HY-151428
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H19F3N2O5Pt
References
– [1]Liu F, et al. Design and biological features of platinum (II) complexes with 3-hydroxy-3-(Trifluoromethyl)cyclobutane-1,1-Dicarboxylate as a leaving ligand. Eur J Med Chem. 2022 Nov 15;242:114673.Â
CAS Number
– 2870703-23-2
Molecular Weight
– 535.38
SMILES
– O=C1O[Pt]2(OC(C13CC(C(F)(F)F)(C3)O)=O)[NH2][C@@H]4CCCC[C@H]4[NH2]2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;COX;Ferroptosis
Isoform
– Bax;Bcl-2;COX-2
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
