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Products Details
Product Description
– Antitumor agent-78 is an antitumor agent, inhibits cancer cells growth and migration. Antitumor agent-78 triggers ferroptosis by inhibiting GPx-4 and elevating COX2. Antitumor agent-78 also activates intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and hinders Epithelial-mesenchymal transition (EMT) process of cancer cells[1].
Web ID
– HY-151428
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H19F3N2O5Pt
References
– [1]Liu F, et al. Design and biological features of platinum (II) complexes with 3-hydroxy-3-(Trifluoromethyl)cyclobutane-1,1-Dicarboxylate as a leaving ligand. Eur J Med Chem. 2022 Nov 15;242:114673.Â
CAS Number
– 2870703-23-2
Molecular Weight
– 535.38
SMILES
– O=C1O[Pt]2(OC(C13CC(C(F)(F)F)(C3)O)=O)[NH2][C@@H]4CCCC[C@H]4[NH2]2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;COX;Ferroptosis
Isoform
– Bax;Bcl-2;COX-2
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
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