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Products Details
Product Description
– Antitumor agent-54 (Compound C11) is a 14-3-3η protein inhibitor with a KD of 35 µM. Antitumor agent-54 shows inhibitory activities against several typical human liver cancer cell lines. Antitumor agent-54 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability[1].
Web ID
– HY-146302
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H32N2O3
References
– [1]Gao Z, et al. Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein. Eur J Med Chem. 2022 Apr 29;238:114402.
CAS Number
– 2770842-10-7
Molecular Weight
– 456.58
SMILES
– COC1=CC=CC(CNCC2=C(N(C3=C2C=CC(C(C)C)=C3)CC4=CC=C(C=C4)C)C(O)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
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