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Products Details
Product Description
– Antitumor agent-123 (Copmound 4d) effectively inhibits multiple kinase targets with anti-cancer effects, including JAK2, JAK3, HDAC1 and HDAC6, with IC50 values of 34.6 and 2.6 μM for JAK2 and JAK3, respectively. Antitumor agent-123 exhibits moderate activity in solid tumor models[1].
Web ID
– HY-149718
Shipping
– Room temperature
Molecular Formula
– C19H14ClFN6O2
References
– [1]Waitman KB, et al. HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents. Eur J Med Chem. 2023 Nov 10;263:115935.
Molecular Weight
– 412.80
SMILES
– ClC1=CC(NC2=C3C(N(CC4=CC=C(C(NO)=O)C=C4)C=N3)=NC=N2)=CC=C1F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;JAK
Pathway
– Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
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