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Antitumor agent-123
SKU
HY-149718-Get quote
Category Reference compound
Tags Cancer, Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt, HDAC;JAK
Products Details
Product Description
– Antitumor agent-123 (Copmound 4d) effectively inhibits multiple kinase targets with anti-cancer effects, including JAK2, JAK3, HDAC1 and HDAC6, with IC50 values of 34.6 and 2.6 μM for JAK2 and JAK3, respectively. Antitumor agent-123 exhibits moderate activity in solid tumor models[1].
Web ID
– HY-149718
Shipping
– Room temperature
Molecular Formula
– C19H14ClFN6O2
References
– [1]Waitman KB, et al. HDAC specificity and kinase off-targeting by purine-benzohydroxamate anti-hematological tumor agents. Eur J Med Chem. 2023 Nov 10;263:115935.
Molecular Weight
– 412.80
SMILES
– ClC1=CC(NC2=C3C(N(CC4=CC=C(C(NO)=O)C=C4)C=N3)=NC=N2)=CC=C1F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– HDAC;JAK
Pathway
– Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.