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Product Description
– Antitumor agent-111 (compound 46) is an c-Met kinase inhibitor (IC50=46 nM) with antitumor and antiproliferative activity. Antitumor agent-111 arrests cell cycle at G0/G1 phase, and induces apoptosis[1].
Web ID
– HY-155544
Shipping
– Room temperature
Molecular Formula
– C34H29ClF2N6O5
References
– [1]Dai J, et al. Design, synthesis and biological evaluation of 4-(4-aminophenoxy)picolinamide derivatives as potential antitumor agents. Eur J Med Chem. 2023 Sep 5;257:115499.
Molecular Weight
– 675.08
SMILES
– O=C(C1=CN(C2=CC=C(F)C(Cl)=C2)C3=C(C=CC=N3)C1=O)NC4=CC=C(OC5=CC(C(NCCCN6CCOCC6)=O)=NC=C5)C(F)=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– c-Met/HGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
