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Products Details
Product Description
– Antitumor agent-104 (Compound 9) is an antitumor agent by inhibiting DNA damage repair in tumors. Antitumor agent-104 inhibits PARP1 enzymatic activity and the PAR protein level. Antitumor agent-104 also inhibits the expression of CDK12[1].
Web ID
– HY-155038
Shipping
– Room temperature
Molecular Formula
– C31H33FN6O3
References
– [1]Lin S, et al. Synthesis of Novel Dual Target Inhibitors of CDK12 and PARP1 and Their Antitumor Activities in HER2-Positive Breast Cancers. ACS Omega. 2023 Jul 7;8(28):25574-25581.
CAS Number
– 2245272-16-4
Molecular Weight
– 556.63
SMILES
– O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(N=C(OCCCN4CCCCC4)N=C5)=C5C3)=O)=C2)C6=CC=CC=C61
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK;PARP
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
