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Products Details
Product Description
– Antiparasitic agent-15, a pyridine-thiazolidinone, has anti-Trypanosoma cruzi and leishmanicidal activities. Antiparasitic agent-15 has IC50s of 0.9 μM and 0.64 μM against trypomastigote and amastigote forms of T. cruzi. Antiparasitic agent-15 has IC50s of 42.2 μM and 9.58 μM against trypomastigote and amastigote forms of L. amazonensis. Antiparasitic agent-15 induces parasite cell death through necrosis induction. Antiparasitic agent-15 induces morphological changes such as shortening, retraction and curvature of the parasite body and leakage of internal content with T. cruzi trypomastigotes[1].
Web ID
– HY-149079
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C17H16N4OS
References
Р[1]Juliana Maria da Concei̤̣o, et al. Structural design, synthesis, and anti-Trypanosomatidae profile of new Pyridyl-thiazolidinones. Eur J Med Chem. 2023 Apr 6;254:115310.
Molecular Weight
– 324.40
SMILES
– CC1(S/C(N(C1=O)C2=CC=CC=C2)=N/N=C/C3=CC=CC=N3)C
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Necroptosis;Parasite
Isoform
– Trypanosoma
Pathway
– Anti-infection;Apoptosis
Product type
– Reference compound
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