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Products Details
Product Description
– Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway[1].
Web ID
– HY-143243
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C24H24N6O
References
– [1]Xie HX, et al. Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway. Bioorg Chem. 2022 Mar;120:105606.
CAS Number
– 2684291-60-7
Molecular Weight
– 412.49
SMILES
– N#CC1=CC=C(C=C1)CN2CCN(CC2)CC3=NOC(CC4=CNC5=CC=CC=C45)=N3
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Keap1-Nrf2;NF-κB;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
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