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Products Details
Product Description
– Antioxidant agent-5 (compound D-6) is a potent antioxidant agent. Antioxidant agent-5 can inhibit oxLDL (oxidized low-density lipoprotein)-induced apoptosis and the expression of ICAM-1 and VCAM-1 in VECs. Antioxidant agent-5 suppresses oxLDL-induced increase of ROS level and nuclear translocation of NF-κB. Antioxidant agent-5 protects against oxLDL-induced endothelial injury by activating Nrf2/HO-1 anti-oxidation pathway[1].
Web ID
– HY-143243
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C24H24N6O
References
– [1]Xie HX, et al. Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway. Bioorg Chem. 2022 Mar;120:105606.
CAS Number
– 2684291-60-7
Molecular Weight
– 412.49
SMILES
– N#CC1=CC=C(C=C1)CN2CCN(CC2)CC3=NOC(CC4=CNC5=CC=CC=C45)=N3
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Keap1-Nrf2;NF-κB;Reactive Oxygen Species
Pathway
– Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
