Download Files:
Products Details
Product Description
– Anticancer agent 141 (compound AE) is an antimycin alkaloid, with inhibitory pottential in HPV infected-cervical cancer. Anticancer agent 141 inhibits cervical cancer HeLa cells proliferation, arrests cell cycle at S phase. Anticancer agent 141 induces caspase dependent apoptosis, via disrupting mitochondrial function, and then activating ROS-mediated ubiquitin-dependent proteasome system, thus mediating E6/E7 oncoproteins degradation[1].
Web ID
– HY-N11877
Shipping
– Room temperature
Molecular Formula
– C28H40N2O9
References
– [1]Zhang W, et al. A novel antimycin analogue antimycin A2c, derived from marine Streptomyces sp., suppresses HeLa cells via disrupting mitochondrial function and depleting HPV oncoproteins E6/E7. Life Sci. 2023 Oct 1;330:121998.
Molecular Weight
– 548.63
SMILES
– OC1=C(C(N[C@H](C(O[C@@H](C)[C@H](OC(C(C)C)=O)[C@H]2CCCCCC)=O)[C@@H](C)OC2=O)=O)C=CC=C1NC(C)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
