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Products Details
Product Description
– Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
Web ID
– HY-149958
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H37N5O5
References
– [1]Hassan NW, et al. Modulating leishmanial pteridine metabolism machinery via some new coumarin-1,2,3-triazoles: Design, synthesis and computational studies. Eur J Med Chem. 2023 May 5;253:115333.
CAS Number
– 2934738-40-4
Molecular Weight
– 511.61
SMILES
– O=C(NCCCCCCN1C=C(N=N1)CN2CCOCC2)C(C(O3)=O)=CC(C=C4)=C3C=C4OCCCC
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Parasite
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
