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Antihistamine-1
$110 – $1,200
Products Details
Product Description
– Antihistamine-1 is a H1-antihistamine (Ki=6.9 nM) with acceptable blood-brain barrier penetration and also an inhibitor of CYP2D6 and hERG channel with IC50s of 5.4 and 0.8 μM, respectively.
Web ID
– HY-100238
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C23H24FN5
References
– [1]Lavrador-Erb K, et al. The discovery and structure-activity relationships of 2-(piperidin-3-yl)-1H-benzimidazoles as selective, CNS penetrating H1-antihistamines for insomnia. Bioorg Med Chem Lett. 2010 May 1;20(9):2916-9.
CAS Number
– 1186430-60-3
Molecular Weight
– 389.47
Compound Purity
– 99.45
SMILES
– CC1=CN(C2CCN(C3=NC4=CC=CC=C4N3CC5=CC=C(F)C=C5)CC2)N=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease; Endocrinology
Solubility
– DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Cytochrome P450;Histamine Receptor;Potassium Channel
Isoform
– CYP2;H1 Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
