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Products Details
Product Description
– Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity[1].
Web ID
– HY-147906
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H13ClF3N5O
References
– [1]Kilic-Kurt Z, et al. Synthesis and anticancer activity of some pyrimidine derivatives with aryl urea moieties as apoptosis-inducing agents. Bioorg Chem. 2020 Aug;101:104028.
CAS Number
– 2453228-45-8
Molecular Weight
– 407.78
SMILES
– NC1=NC(NC(NC2=CC=C(C(C(F)(F)F)=C2)Cl)=O)=CC(C3=CC=CC=C3)=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PARP
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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