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Product Description
– Anticancer agent 63 (compound 3h) shows active in reducing the viability of different cancer cell lines, including SW480, HeLa, A549 and MCF-7, with IC50 values at 24 h of 4.9, 11.5, 9.4, and 3.4 μM, respectively. Anticancer agent 63 induce apoptosis in MCF-7 cells via down-regulating the expression of Bcl-2 and up-regulating the expression of IL-2 and Caspase-3. Anticancer agent 63 also shows antioxidant activity[1].
Web ID
– HY-147504
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C17H24F3NOSe
References
– [1]He X, et al. Synthesis and biological evaluation of organoselenium (NSAIDs-SeCN and SeCF3) derivatives as potential anticancer agents. Eur J Med Chem. 2020 Dec 15;208:112864.
CAS Number
– 2529657-32-5
Molecular Weight
– 394.33
SMILES
– CC(CC1=CC=C(C=C1)C(C(NCCC[Se]C(F)(F)F)=O)C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;Caspase
Isoform
– Bcl-2;Caspase 3
Pathway
– Apoptosis
Product type
– Reference compound
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