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Products Details
Product Description
– Anticancer agent 59 (compound 11) has inhibitory activity against kinds of cancer cell lines, especially in A549 with IC50 of 0.2 μM. Anticancer agent 59 induces apoptosis and an increase of Ca2+ and ROS in cancer cells. Anticancer agent 59 significantly decreases mitochondrial membrane potential. Anticancer agent 59 can suppress tumor growth in A549 mouse xenograft model[1].
Web ID
– HY-146462
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C42H59NO6
References
– [1]Yin Y, et al. Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with l-phenylalanine or l-proline [published online ahead of print, 2022 May 11]. Bioorg Chem. 2022;126:105865.
Molecular Weight
– 673.92
SMILES
– O=C([C@]1(CC[C@@]2(CC[C@@]3(C([C@@]2(C1)[H])=CC(C4[C@]5(CC[C@@H](C(C)(C5CC[C@]43C)C)OC(CC)=O)C)=O)C)C)C)N[C@@](CC6=CC=CC=C6)(C(O)=O)[H]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;ROS Kinase
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
