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Products Details
Product Description
– Anticancer agent 58 (compound 16) has inhibitory activity against kinds of cancer cell lines, especially in A549 and T24 with IC50s of 0.6 μM and 0.7 μM, respectively. Anticancer agent 58 induces apoptosis by activating caspase 3/8/9 activity, and induces an increase of Ca2+ and ROS in cancer cells. Anticancer agent 58 significantly decreases mitochondrial membrane potential. Anticancer agent 58 can suppress tumor growth in T24 mouse xenograft model[1].
Web ID
– HY-146461
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C39H55NO5
References
– [1]Yin Y, et al. Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with l-phenylalanine or l-proline [published online ahead of print, 2022 May 11]. Bioorg Chem. 2022;126:105865.
Molecular Weight
– 617.86
SMILES
– [H][C@](CC1=CC=CC=C1)(C(O[C@H]2CC[C@]3(C(C2(C)C)CC[C@@]4(C3C(C=C5[C@]4(CC[C@]6(CC[C@](C(O)=O)(C[C@@]56[H])C)C)C)=O)C)C)=O)N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Caspase;ROS Kinase
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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