Download Files:
Products Details
Product Description
– Anticancer agent 135 (compound 26h) is a potent androgen receptor (AR) antagonist. Anticancer agent 135 can effectively block AR nuclear translocation and inhibit AR/AR-V7 heterodimerization, thereby inhibiting downstream gene transcription. Anticancer agent 135 displays potent robust efficacy in prostate cancer xenograft models[1].
Web ID
– HY-155543
Shipping
– Room temperature
Molecular Formula
– C23H21F3N4OS
References
– [1]Xiujin Chang, et al. Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer. Eur J Med Chem. 2023 Sep 5;257:115490.
Molecular Weight
– 458.50
SMILES
– FC(F)(C1=C(C=CC(N2C(N(CC2=O)CCCN3C4=CC=CC=C4CCC3)=S)=C1)C#N)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Androgen Receptor
Pathway
– Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
